I was very lucky that the OD'S i did didn't cause any brain damage though I never had migraines or even headaches before that....thkugh my neuroligist at that time (late 90's) thoughtbfore sure the migraines came from a neck injury years before but made it necessary to have neck fusion.
My major depression got better when I left the bad marriage environment I had lived in for 33 years. It was amazing because without living in the stressful environments, my brain could remember more, learn more & converse better & even realize the emotional connections that had been missing all my life. It was like starting life completely over at the age of 54.....
So what I realized in my situation was that living surrounded by stress all my life was the cause of my problems even though I got my degree & had a computer engineering career for 15 years before the breakdown....it had beem building up to that point all my life. Being free from that environment let the internal me out to be free to be what I always thought life should be like.