I've been on meds so long now, and on so many different ones, but I feel like they just don't really work. I still take them though, and I continue to see my pilldoc. I have quit Cymbalta twice cold turkey, which wasn't fun, and not advised, but that's the only med I've ever done that with. I have given up fighting the meds, even though I doubt their efficacy. I just do what my therapist and psychiatrist say to do. Oh....and I recently just had a genetic biomarker test done to see what classes of meds are compatible with my body. Haven't got the results yet. After 25 years of taking meds, I'm surprised this is the first time I've ever had this done, but maybe it will shed some light on things.