Im on wellbutrin XL for about the past 2 years, recently my Nurse Practitioner raised the dose to 450mg once a day. Ive had no negative side effects that I can notice. Currently on Effexor 225 mg and the 450 mg Wellbutrin XL. I had been on Rexulti with the effexor and 300 mg wellbutrin, but I couldnt control my cravings for FOOD. So I had to get off of it.