I suppose a good rule of thumb is if one finds reading their own post
↑ induces headaches and agitation then...
Humane Version
Replaced 16yr old's Abilify with Seroquel because the Abilify no longer worked satisfactorily.
At some point, noticed unusual agitation, along with expected sedation and onset of a few EPS. Hypomania/perseverance abates.
Anger and increasing disconsolance become concerning, its decided to reestablish a new baseline at a slower pace.
Tapered down, extreme irritation, rants subsided, sedation subsides, hypomania increases to high levels. Slower taper back up with Seroquel, results: At the point sedation manifests, frustration tolerance at zero, hyper-irritation, rants now hours-long and intense.
We've decided to notify PsyMD of our intention to withdraw the Quetiapine Furmate.
Follow Up
Wife and I recalled this evening that he doesn't handle sedatives well at all - especially coming off of them. Seems like a pediatrician had told us once that he should never drink - or was it to never take tranquilizers? - based on his reaction to some sedative DS had been given.
Safe to say that future considerations should probably emphasize those medications that don't have major-tranquilizer-type sedation as a main property.