Lamictal was a wonder med for me. Unfortunately I did develop SJS and had to stop taking it. Autistic people with family with autoimmune illness should probably not take this med, and if the patient himself has any autoimmunities, they should absolutely not take Lamictal. They did not know this when I tried it. Too bad. It wasn't like gabapentin or anything like that for me.

If autism coexist with ADD/ADHD, a stimulant might help. Sometimes when they coexist, stimulants still don't help and can create problems. Different for different people.

Some people with autism tolerate neuroleptics quite well, but I seem to really need my dopamine. The only one in this class I tolerated at least a bit was Risperdal. The other ones, Seroquel, Geodon, made me feel like I was in HELL. Maan! It is hard to explain. I feel like the world is sometimes too close to me. Neuroleptics made me feel like I was even way closer to the world, and everything was hyper real. Like every impression, every thought, really got to me. Like I had no protection from anything. The world mentally scorched me.

Luckily I stopped having anger issues after getting on Luvox, sometimes other SSRIs can help as well. But all people don't have that kind of luck. It actually made me have a little more protection from the "world" but the med that helped most with that part was a benzo, and you don't give those to kids. About SSRIs, it is not like if you tried one you tried them all, I have tried several and all of them gave me different reactions.

My anger stemmed from everything being too close and getting to me. It is kind of hard to explain. I couldn't drop negative emotion, it just built up.

If he responds well to Benadryl, you could try the antihistamine path. Antihistamines are brutally sedative to me, even the non sedating ones. But we're all different. Antihistamines in psychiatric treatment are for example Vistaril, prometazine and doxylamine.

Personally SSRI+benzo dealt well with irritability and Ritalin made me less "autistic" even if they claim it makes autistic people more autistic. I was unhappy about being less though, so I just take it on rare occasions.