I started on Zoloft a few months ago because it was said to be less likely to cause weight gain. I was taking 40 mg of Paxil and it was difficult to keep my weight down. I started taking 100 mg of Zoloft and found that it did indeed make me less hungry and I was starting to lose some weight. I went up to 150 mg of Zoloft for awhile. I started experienced extreme anxiety while on Zoloft. I thought it would get better as time went on. However, the longer I stayed on Zoloft, the worse my anxiety got. I finally had my psychiatrist put me back on Paxil. It took about two months before my anxiety was again under control. I don’t know if others have had this problem with Zoloft or not but I would certainly be interested in hearing if others have had the same experience. Paxil appears to be my drug of choice to keep my anxiety under control.