I take Wellbutrin, Zoloft and Effexor (do not ask why three antidepressants) for anxiety and depression.

I have got bipolar disorder, but we tapered it up very slowly and there are two mood stabilizers to keep things leveled out.
Wellbutrin was definitely activating. (as the doctor said it would be- helps with anhedonia and hypersomnia)

I did not lose weight, but my appetite was suppressed.