I guess a few meds qualify. Zyprexa, Trilafon (perphanazine), and Geodon. The Zyprexa and Trilafon really worked great at controlling my moods and making me feel more normal, but both made me gain weight rapidly and Zyprexa also gave me akathisia. Geodon was very weight friendly and initially helped well, but then its maximum dose stopped being effective enough to control my mania, and later down the line it gave me horrible akathisia. I would agree to take Zyprexa or Trilafon again simply as short-term "emergency" only medications, but only short-term.

Which medication gave you the most or absolute most unbearable side effect(s)?