hi. id personally dose at night, unless you have to work at night or something. one thing i did like about the patented, still expen$ive Tofranil-PM was that it seemed to get the job done a bit better than the old school generic, plus its just one capsule, at night.

some tca drugs are dosed throughout the day. elavil and the elavil combo pills (limbitrol, triavil) are often taken daytime. I have no idea how anyone tolerates that stuff, but...yeah.