I was on sertraline once for about five months while going through some horrendous work-related stress. When I got up to a dose of 75 mg, after a few days I started feeling side effects (felt like I had a brick at the base of my skull), and backed down to the previous dose of 50 mg for a couple more months.

When I finally decided to discontinue it, I alternated between 50 and 25 for a while, then just 25 mg, then 25 on alternate days and then discontinued. It was about 15 years ago and I can't remember exactly how long it took, but I do remember the way I alternated dosages to make for a more gradual transition.