I was taken off 150 Effexor over a year ago and since then have tried every antidepressant, mood stabilizer, antieleptic and everything else under the sun but I had adverse reactions to all of them. Even tried going back on Effexor but it didn't work. My doctor and I are at an impasse. I went for a second opinion and this doctor would not treat me - said I had treatment resistant depression and suggested undergoing ECT treatments. I immediately and adamantly refused because it sounds so scary and I guess I have visions of scenes from One Flew Over the Cuckoo's Nest!! Would appreciate any feedback regarding ECT. I'm trying like hell to do this on my own without any more antidepressants, as I take Seroquel and Trazodone at night and my doctor advised that they do have antidepressant properties. My quality of life sucks right now but I'm scared to death of the alternative treatment. Your opinions would really help me out a lot and mean the world to me. So glad I found this forum.