I take it in combination with Trintellix, another AD. I also take an AP. and and ADHD med. The Cymbalta does not seem to have any bad side effects for me. IIRC it did take a bit for it to kick in, maybe three or four weeks. We had to raise the dose from 30 mg to 60 mg. Then I started seeing the "therapeutic benefit." It did not affect my sleep (I take it in the morning). I don't think I gained weight on it though I gain weight on my AP which I take at the same time so I can't be certain of that.