Definitely. I've been on and off medications many times in the past. A lot of times because I felt like the "real me" was the unmedicated me. I felt like I had lost touch with the intensity of my emotions, good and bad, as well as dampened my creativity with medications.
Over the years I've realized that the consequences of the disorder are far worse than the side effects of the medication. I don't mind not having as intense of depressions as before, and I also can still be creative on the medication. It's just that fewer of my creative bursts are from pain.