Like what's been said already , it really does depend on what works for you and your diagnosis. But if you haven't responded to AD's then definitely try AP's, that's my advice. I already said this in another post so I don't want to sound like someone that's preaching this but if you are MDD, or I call it unipolar depression, figure out which symptom is your main depressive symptom, sadness or anhedonia. That's according to this, not me: "At least five symptoms must occur for a DSM diagnosis of major depressive disorder (MDD), one of which must be sadness or anhedonia." PMC3688280

Just my opinion! But you shouldn't have to even guess which one, I most definitely didn't. If you don't have MDD, then you might need to disregard what I said above as that might need a different approach as far as meds.