Delayed reaction to cold meds ect

My question that no DR. or person has been able to answer is this: As of the last 10 years or so, if I take Nyquil ,cold meds, drink "1 beer" etc... NOT UNTILL 4 DAYS LATER will I have MAJOR difficulty keeping stress down (even about past issues). And like I said, ”1 beer” or cold medicine will do this. And it can be realy bad at moments, explosive and very dangerous. THIS WILL LAST 4 MORE DAYS Now granted, my life for the past x amount of years has been extremely stressful almost daily and I have a ton of baggage Im trying to get past . But this issue has happend even without stressfull times...This issue is what is cripling me from getting past and on with healing. I have insomnia now and Im very afraid to take anything. So I can see being on edge.. But this is amplified. I can even be in a decent space that week, on vacation and decide to have a beer… so no real time stressors, except 4 days later. This has got to be a brain chemistry thing. I have taken different depression meds for 27 years and smoke alittle indica in the evening only (only thing that makes me relax and take another breath to try again). I have tried switching all my meds, even quiting smoking and quitting all meds... something is wrong with my brain and its killing me (or will kill me someday). I have tracked this on a calander at times, its very real and not my imagination..

Has anybody experienced this? have any links that address this?
Please; I dont need a lecture on the smoking (it hasnt allways been a variable) .

Any ideas? Point me in a better direction to find answer? Every DR. I have had has no idea..
Thanks in advance.

No lectures from me. Questions though, since yeah of course the anticipation of some type of delayed reaction sounds horrendous in and of itself.
This happens with or without being rested?
When you say explosive, is that temper or the anxiety/panic attack is explosive in its onset? You've been treated for depression but not anxiety in the past, am I understanding correctly?
Does your mood go haywire or is it full blown palpitations, sweating, jitters?

OMG, I am so sorry for missing/ not responding to your reply. ( I dont recall seeing an email letting me know of your reply).
So if your still around here are answers to your questions:
The issue happens both when I haven't rested and when I have rested (until past year rest hasn't been an issue ). However this "episode" will cause some sleepless nights in itself .
The explosiveness /rage hapends when I am triggered about a past event (allways the same) (or when I am currently randomly stressed )that I have not been able to reconcile (same triggers for 10 years) . Sometimes I am able to keep it at bay but during these "episodes" its near impossible. I must say that the explosiveness or rage I do keep to myself but its killing me . I have always done COG therapy, some mindfulness, meditation. The treatment has been for General Anxiety and mild/moderate depression and some ADD. I take 150 mg welbutrin and 200mg Lamictal (both generic).. Thru the years I have tried many to see if problem would go away but it doesn't. My mood just goes south, only physical is after a short bit... there is panic, anxiety, fear, resentment, hatred (specific individuals that have caused my pain) and hopelessness.... I am not a violent person and couldn't hurt another person, but when its like this I feel I have to die to make this all go away.... thats when it gets scary. Only physical is thighness in neck (normal for anger) and when it gets terrible some hyper venation.
It probably goes without saying that I also have this problem when I go down to off a medication. I have bad insomnia since last october with little help from meds. it may be the lamical but Im VERY afraid to go down that long road of getting off it (in reading my past journals when going down on it IT WAS BAD MENTALLY).
I find it hard to believe that not allot of others have this problem.
Thanks for the reply if your still listening.