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Default Nov 14, 2019 at 10:59 PM
  #1
Hi everyone,
I have been going downhill. Seems to be the early signs of a mixed episode. I've been increasingly depressed, but also have been feeling paranoid and experience delusions and racing thoughts.

I am on Latuda (20mg), along with my other 4 meds. My pdoc decided to increase the Latuda to 40 mg. I have not tried 40 mg yet. I am wondering if anyone else can share their experiences when their Latuda was increased, or if you happen to be on 40mg. Do you get side effects? How is it helping you in terms of symptoms? I hope I do not gain weight or experience any TD/restlessness. I have been tolerating 20 mg okay. All I want is to feel better.

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Default Nov 14, 2019 at 11:40 PM
  #2
Hi, I was on Latuda for exactly one year. About 4 months in my dose was increased to 40mg and a bit later to 60mg.


I did not gain weight from the Latuda (I sure did from Seroquel). I did not experience akathesia (restlessness/agitation). I did develop a pretty severe tremor (hands). When the tremor started in my jaw my pdoc stopped the Latuda right away.


Do you know, 40mg is still on the low end?

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Default Nov 14, 2019 at 11:49 PM
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When I was on it I didn’t have any bad side effects when we increased it, highest I was on was 80mg a day. I know initially when I was put on it it DID help level me out.

But I quit it for issues of metabolic syndrome.

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Default Nov 14, 2019 at 11:53 PM
  #4
I did great on latuda. My dr switched me to haldol because of psychosis but it was great for depression and mixed stuff. No weight gain.

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Default Nov 15, 2019 at 12:01 AM
  #5
I'm on 80 mg it's been great for the BP but caused metabolic syndrome witch I have put up with cause the BP is so controlled. I don't really remember back on 40 mg. I know it caused some side effects and I switched to taking it at bedtime so I could sleep though them, those side effects went away as I got used to the meds.

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Smile Nov 15, 2019 at 09:15 AM
  #6
Hi,
I am on 40 mg and it works great along with my other meds. Absolutely no weight gain for me. I was on 20 mg, but after I became depressed after maybe a year, my doctor upped it to 40 mg and so far it has worked.

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Default Nov 15, 2019 at 01:33 PM
  #7
hi. sorry about this :-(

I just take Abilify...I'm just popping in because I'm glad to see you posting and because Latuda has been mentioned/pushed on me here and there. Anyway...

with 2 antipsychotics on board, there is a risk of akathisia, eps, etc. TD is usually something that'd pop up after a long(er) time on treatment. My personal, just me, suggestion would be to ask the psych if there's a way to settle on 1 antipsychotic, for the long haul. antipsychotic+antipsychotic combinations are sometimes helpful, but most of the data that says it might be good for some people comes from clozapine+other antipsychotic combinations, and that's mostly in people who both have severe illness -and- deal with being treatment resistant.

ok. one drug that's been recommended to me by a former psych, then shot down by this psych (clinic...they come and go...) is amoxapine. It is a tca, so no-no if you have heart probs, seizures, hate tca drugs, or OD. but...

its not all that commonly used, now, but its a kind of classic selection for psychotic depression, apparently. the 1 drug is metabolized and turns into a couple things...including loxapine, an older antipsychotic that came to market in the 70s. loxapine is more atypical-ish than most of the other older ones, it just never caught on like...Haldol. blah. anyway....

so, I think there's NE action and serotonin action, plus the loxapine. Its sedating, taken at bedtime. generic. in severe and/or psychotic depression, -when- it helps, it often somehow seems to act somewhat faster than other antidepressants...think 1-2 weeks, if it is going to do anything helpful.

i just mentioned this because i saw some small studies that found it -might- be an atypical antipsychotic in disguise...at high enough doses, it seems to control all aspects of psychosis as well as Haldol, better tolerability than risperidone.

other than that...again, again, again; I'm going to push vitamins on you. lol. seriously. I think the b-100+ c+ natural form E has really, really helped me tolerate Abilify...10ish years into treatment, no EPS, no TD. true story.
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Default Nov 15, 2019 at 04:41 PM
  #8
Quote:
Originally Posted by BethRags View Post
Hi, I was on Latuda for exactly one year. About 4 months in my dose was increased to 40mg and a bit later to 60mg.


I did not gain weight from the Latuda (I sure did from Seroquel). I did not experience akathesia (restlessness/agitation). I did develop a pretty severe tremor (hands). When the tremor started in my jaw my pdoc stopped the Latuda right away.


Do you know, 40mg is still on the low end?
Hi, I did not know 40 mg was still on the low end. I guess my pdoc wants to taper until it starts to work? I am maxed out on my Lamictal and pretty high up on my other meds....so I hope this works so that my pdoc doesn't have to change everything around.

I'm sorry you experienced tremor. Did you start to experience the tremor on 40 mg or 60mg?

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Default Nov 15, 2019 at 04:49 PM
  #9
Quote:
Originally Posted by still_crazy View Post
hi. sorry about this :-(

I just take Abilify...I'm just popping in because I'm glad to see you posting and because Latuda has been mentioned/pushed on me here and there. Anyway...

with 2 antipsychotics on board, there is a risk of akathisia, eps, etc. TD is usually something that'd pop up after a long(er) time on treatment. My personal, just me, suggestion would be to ask the psych if there's a way to settle on 1 antipsychotic, for the long haul. antipsychotic+antipsychotic combinations are sometimes helpful, but most of the data that says it might be good for some people comes from clozapine+other antipsychotic combinations, and that's mostly in people who both have severe illness -and- deal with being treatment resistant.

ok. one drug that's been recommended to me by a former psych, then shot down by this psych (clinic...they come and go...) is amoxapine. It is a tca, so no-no if you have heart probs, seizures, hate tca drugs, or OD. but...

its not all that commonly used, now, but its a kind of classic selection for psychotic depression, apparently. the 1 drug is metabolized and turns into a couple things...including loxapine, an older antipsychotic that came to market in the 70s. loxapine is more atypical-ish than most of the other older ones, it just never caught on like...Haldol. blah. anyway....

so, I think there's NE action and serotonin action, plus the loxapine. Its sedating, taken at bedtime. generic. in severe and/or psychotic depression, -when- it helps, it often somehow seems to act somewhat faster than other antidepressants...think 1-2 weeks, if it is going to do anything helpful.

i just mentioned this because i saw some small studies that found it -might- be an atypical antipsychotic in disguise...at high enough doses, it seems to control all aspects of psychosis as well as Haldol, better tolerability than risperidone.

other than that...again, again, again; I'm going to push vitamins on you. lol. seriously. I think the b-100+ c+ natural form E has really, really helped me tolerate Abilify...10ish years into treatment, no EPS, no TD. true story.
Thank you for all this info! I definitely want to look into this and ask my pdoc. Plus, I admit I haven't been taking enough Vitamins. I guess with all the pills, it makes it easy for me to forget, but I shouldn't be forgetting! I do hope I can get taken off of 2 AP's. More than anything, I just want my mood to even out without terrible side effects.

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Default Nov 15, 2019 at 06:54 PM
  #10
Hi xRavenx. Glad to see you posting about Latuda. I'm sorry to read that your depression/mixed symptoms are breaking through. I remember you and I starting the 20 mg of Latuda at almost the same time. I am still on 20 mg, so I don't have any experience to share at a higher dose. I have actually had medication changes on it, but mostly my Seroquel XR up and down for symptoms more on the manic end, or mixed. My psychiatrist favors my Seroquel XR. He had only really tried the Latuda on me because way back when I complained about feeling dull. I'll admit that the small 20 mg dose did me a lot of good in that respect.

I have zero side effects from 20 mg. It is disconcerting to read that others have been affected by Latuda metabolically. It has been weight neutral for me at the 20 mg dose. I don't know if it adds to my previously high cholesterol/triglycerides.
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Default Nov 15, 2019 at 07:35 PM
  #11
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Originally Posted by BirdDancer View Post
Hi xRavenx. Glad to see you posting about Latuda. I'm sorry to read that your depression/mixed symptoms are breaking through. I remember you and I starting the 20 mg of Latuda at almost the same time. I am still on 20 mg, so I don't have any experience to share at a higher dose. I have actually had medication changes on it, but mostly my Seroquel XR up and down for symptoms more on the manic end, or mixed. My psychiatrist favors my Seroquel XR. He had only really tried the Latuda on me because way back when I complained about feeling dull. I'll admit that the small 20 mg dose did me a lot of good in that respect.

I have zero side effects from 20 mg. It is disconcerting to read that others have been affected by Latuda metabolically. It has been weight neutral for me at the 20 mg dose. I don't know if it adds to my previously high cholesterol/triglycerides.

Thanks, Bird Dancer. I am glad to hear that the small Latuda dose worked out well for you without side effects. I am also on Seroquel, but not the XR (although I used to be). I go up and down on the Seroquel, depending on symptoms. Since I tolerate the 20 mg of Latuda, hopefully this will continue with the dosage increase.

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Default Nov 16, 2019 at 04:44 PM
  #12
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Originally Posted by xRavenx View Post
Hi, I did not know 40 mg was still on the low end. I guess my pdoc wants to taper until it starts to work? I am maxed out on my Lamictal and pretty high up on my other meds....so I hope this works so that my pdoc doesn't have to change everything around.

I'm sorry you experienced tremor. Did you start to experience the tremor on 40 mg or 60mg?

Yes...if I correctly recall 60mg is the start of a target dose.


I started experiencing the jaw tremor at 60mg, or even higher...it seems to me that I was on 80mg by the time the pdoc stopped the med.

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