advertisement
Reply
 
Thread Tools Display Modes
Old 08-18-2012, 06:18 PM   #1
Blue Poppy
Veteran Member
 
Blue Poppy's Avatar
Blue Poppy has no updates.
 
Member Since: Jul 2012
Location: Canada
Posts: 335
8 yr Member
22 hugs
given
Default Being Bipolar and SSRI's - a question

Hello there,

I apologize, this is a bit long winded.

When I had a severe meltdown, my first one, two years ago, the pdoc recommended that I go off Paxil because he didn't think it was working anymore.

After the first year, the diagnosis changed from major depression to bipolar II. However, being without Paxil has been two years of hell.

When I asked to go back on it several times, he explained the preference and clinical reasons why SSRI's and bipolar don't mix well. So I have been through a few SNRI's (I think this is the acronym, but I may have it wrong) which I was told were better for my diagnosis. I have tried wellbutrin and effexor.

Last summer I was so hypomanic on the wellbutrin and effexor that I lost 35 pounds, and I am not overweight. I was a skeleton and I was grey.

I requested Paxil three weeks ago, since I was heading down the road of another depression. It has been a little more than three weeks, and the past three days have been different. Even my friends have told me that there is a noticeable difference in me this past week. The light has returned in my eyes.

So my question is, why are the SSRI's frowned upon? I see that several of you are on prozac, zoloft etc.

I don't know what it is about my brain chemistry, but I do much better with an SSRI.

Thanks for you answers in advance.
Blue Poppy is offline   Reply With QuoteReply With Quote

advertisement
Old 08-18-2012, 06:20 PM   #2
Trippin2.0
Legendary
 
Trippin2.0's Avatar
Trippin2.0 seemingly lost inside her own head….
 
Member Since: May 2010
Location: Cape Town South Africa
Posts: 11,937 (SuperPoster!)
10 yr Member
614 hugs
given
PC PoohBah!
Default Re: Being Bipolar and SSRI's - a question

I'm not too sure, think they have a greater chance of inducing mania... I could be wrong tho.
Trippin2.0 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Old 08-18-2012, 06:34 PM   #3
Kristiemarie
Member
Kristiemarie has no updates.
 
Member Since: Aug 2012
Posts: 212
8 yr Member
6 hugs
given
Default Re: Being Bipolar and SSRI's - a question

I think It's because thy can induce or make mania worse. I also think that they sometimes dont work long term with bp. I say this because it's one of the reasons my pdoc mentioned bp as a diagnosis to me. I've been on Prozac, Zoloft, Wellbutrin, Pristiq and combos of them. All which seem to work and then crap out after a while.

But if it works for you, I don't know why you shouldn't be on them. Maybe someone who is better versed in meds will help you out.
Kristiemarie is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Old 08-18-2012, 08:43 PM   #4
cocoabeans
Poohbah
 
cocoabeans's Avatar
cocoabeans has no updates.
 
Member Since: Jan 2012
Posts: 1,122
8 yr Member
Default Re: Being Bipolar and SSRI's - a question

As far as I know it's all antidepressants that are avoided with bipolar. That's in the "ideal" world where a mood stabilizer on it's own does the trick or when you're not depressed. They're not always effective at helping bipolar depression nor preventing it and can make things worse, that includes SNRIs and others. Of course, psychiatry is all about trial and error so, when the first approach doesn't work, another one is attempted and the "rules" are broken on an case by case basis.

I haven't read anything about SNRIs working better for bipolar depression but, as a second choice after a trial or two on an SSRI makes sense.

In case you're curious, Wellbutrin isn't an SNRI or SSRI, it's in its own class. It affects norepinephrine and dopamine. That's why it decreases appetite and is often prescribed with an SSRI and helps with quitting smoking and was marketted as Zyban. Same drug, different name to increase sales. It's also a third or fourth line drug for ADHD because of the stimulant effects.

SNRIs approved for depression are Cymbalta, Effexor and Pristiq. Pristiq is actually Effexor but, a more potent version that was put on the market because the patent on Effexor ran out, it's just a drug company scheme to keep profits. A lot like Symbyax (which is just Zyprexa and Prozac) released after both drugs were off patent.

Enough of the tangent!
cocoabeans is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Old 08-18-2012, 09:34 PM   #5
~Christina
Legendary Wise Elder
Community Liaison
 
~Christina's Avatar
~Christina has no updates.
 
Member Since: Jul 2011
Location: Tennessee
Posts: 20,439 (SuperPoster!)
8 yr Member
9,820 hugs
given
PC PoohBah!
Default Re: Being Bipolar and SSRI's - a question

SSRI's flip me right into full blown mania .
__________________
Helping others gets me out of my own head ~
~Christina is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Old 08-18-2012, 10:00 PM   #6
Confusedinomicon
Magnate
Confusedinomicon has no updates.
 
Member Since: Feb 2011
Location: Antarctica
Posts: 2,164
8 yr Member
151 hugs
given
PC PoohBah!
Default Re: Being Bipolar and SSRI's - a question

I took a SSRI by itself and had hypomanic symptoms, but when I took it with a mood stabilizer I didn't have problems.
__________________
"You got to fight those gnomes...tell them to get out of your head!"
Confusedinomicon is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Old 08-18-2012, 11:44 PM   #7
Blue Poppy
Veteran Member
 
Blue Poppy's Avatar
Blue Poppy has no updates.
 
Member Since: Jul 2012
Location: Canada
Posts: 335
8 yr Member
22 hugs
given
Default Re: Being Bipolar and SSRI's - a question

Quote:
Originally Posted by Confusedinomicon View Post
I took a SSRI by itself and had hypomanic symptoms, but when I took it with a mood stabilizer I didn't have problems.
That is very interesting! I hope that the same happens for me.
Blue Poppy is offline   Reply With QuoteReply With Quote
Old 08-18-2012, 11:45 PM   #8
Blue Poppy
Veteran Member
 
Blue Poppy's Avatar
Blue Poppy has no updates.
 
Member Since: Jul 2012
Location: Canada
Posts: 335
8 yr Member
22 hugs
given
Default Re: Being Bipolar and SSRI's - a question

Quote:
Originally Posted by cocoabeans View Post
As far as I know it's all antidepressants that are avoided with bipolar. That's in the "ideal" world where a mood stabilizer on it's own does the trick or when you're not depressed. They're not always effective at helping bipolar depression nor preventing it and can make things worse, that includes SNRIs and others. Of course, psychiatry is all about trial and error so, when the first approach doesn't work, another one is attempted and the "rules" are broken on an case by case basis.

I haven't read anything about SNRIs working better for bipolar depression but, as a second choice after a trial or two on an SSRI makes sense.

In case you're curious, Wellbutrin isn't an SNRI or SSRI, it's in its own class. It affects norepinephrine and dopamine. That's why it decreases appetite and is often prescribed with an SSRI and helps with quitting smoking and was marketted as Zyban. Same drug, different name to increase sales. It's also a third or fourth line drug for ADHD because of the stimulant effects.

SNRIs approved for depression are Cymbalta, Effexor and Pristiq. Pristiq is actually Effexor but, a more potent version that was put on the market because the patent on Effexor ran out, it's just a drug company scheme to keep profits. A lot like Symbyax (which is just Zyprexa and Prozac) released after both drugs were off patent.

Enough of the tangent!
I liked your tangent! Very informative, thanks so much!
Blue Poppy is offline   Reply With QuoteReply With Quote
Old 08-18-2012, 11:46 PM   #9
Blue Poppy
Veteran Member
 
Blue Poppy's Avatar
Blue Poppy has no updates.
 
Member Since: Jul 2012
Location: Canada
Posts: 335
8 yr Member
22 hugs
given
Default Re: Being Bipolar and SSRI's - a question

Quote:
Originally Posted by Kristiemarie View Post
I think It's because thy can induce or make mania worse. I also think that they sometimes dont work long term with bp. I say this because it's one of the reasons my pdoc mentioned bp as a diagnosis to me. I've been on Prozac, Zoloft, Wellbutrin, Pristiq and combos of them. All which seem to work and then crap out after a while.

But if it works for you, I don't know why you shouldn't be on them. Maybe someone who is better versed in meds will help you out.
Oh I will be so sad if Paxil craps out!
Blue Poppy is offline   Reply With QuoteReply With Quote
Old 08-19-2012, 12:50 AM   #10
BlackPup
Magnate
 
BlackPup's Avatar
BlackPup has no updates.
 
Member Since: Jun 2010
Location: Australia
Posts: 2,861
10 yr Member
614 hugs
given
PC PoohBah!
Default Re: Being Bipolar and SSRI's - a question

SNRIs are more likely to put you into mania than SSRIs because they (SNRIs) affect both the serotonin and noradrenalin were as SSRIs are selective serotonin reuptake inhibitors.
Don't know why your doc won't let you try them
__________________
I can do all things through him who gives me strength
BlackPup is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -5. The time now is 10:14 AM.

Powered by vBulletin® — Copyright © 2000 - 2020, Jelsoft Enterprises Ltd.



 

advertisement

Psych Central Forums

Psych Central is the leading mental health website, overseen by mental health professionals since 1995.

 

Helplines and Lifelines

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.

Always consult your doctor or mental health professional before trying anything you read here.
Please read the full disclaimer.