SSRI induced mania/psychosis. Have you had it? - Forums at Psych Central



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Old 06-19-2016, 06:27 PM #1
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Default SSRI induced mania/psychosis. Have you had it?

Have you ever been thrown into a severe manic episode because of an antidepressant like Prozac? What about psychosis? Were you on a mood stabilizer at the time? How certain are you that the ssri caused it and not something else? How bad was your psychosis/mania and how long did it last?

For me, I took Prozac and became severely manic, which led to a lot of bad things, and ended in a 10/10 worse psychosis ever. Lasted 3 weeks and I ended up in jail, with essentially full blown schizophrenia for the time being. I've never had psychosis before that, and am completely fine now that I'm off it and on lithium. Stress was also a big factor. Being manic lead me to do mushrooms which probably had an impact. I was smoking weed daily as well, but I had already been doing that for the previous 5 years with no problems until I started taking Prozac, yet the doctors still insist it was "cannabis induced psychosis" and had nothing to do with the Prozac.....
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Old 06-19-2016, 06:47 PM #2
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Default Re: SSRI induced mania/psychosis. Have you had it?

Celexa sent me into a mixed state twice, even though I was also in abilify. Prozac sent me soaring into mania, which degenerated into psychosis and ended with an inpatient stay after a severe self harm incident. That was partially my fault bc I refused to take a mood stabilizer because I wanted the mania.
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Old 06-19-2016, 07:10 PM #3
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Default Re: SSRI induced mania/psychosis. Have you had it?

Quote:
Originally Posted by Th3reandback View Post
Have you ever been thrown into a severe manic episode because of an antidepressant like Prozac? What about psychosis? Were you on a mood stabilizer at the time? How certain are you that the ssri caused it and not something else? How bad was your psychosis/mania and how long did it last?

For me, I took Prozac and became severely manic, which led to a lot of bad things, and ended in a 10/10 worse psychosis ever. Lasted 3 weeks and I ended up in jail, with essentially full blown schizophrenia for the time being. I've never had psychosis before that, and am completely fine now that I'm off it and on lithium. Stress was also a big factor. Being manic lead me to do mushrooms which probably had an impact. I was smoking weed daily as well, but I had already been doing that for the previous 5 years with no problems until I started taking Prozac, yet the doctors still insist it was "cannabis induced psychosis" and had nothing to do with the Prozac.....
The diagnosis is substance induced mood disorder or substance-/medication-induced BP (depending on DSM), so I wouldn't worry too much about what they think.

That they made explicit the medication bit in the name of the new diagnosis and they changed it to BP is a reflection of a growing understanding that serotonergic drugs (like fluoxetine) may cause mania.

I never had the misfortune of being exposed to SSRIs. I did however use 5-HTP, which is a serotonin precursor, which (probably) caused a mild mixed state (starting with mania).
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Old 06-19-2016, 07:19 PM #4
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Default Re: SSRI induced mania/psychosis. Have you had it?

I can't take antidepressants for the most part because of SSRI-induced hypomania. It's unfortunate, too, because of my OCD. But it's okay. I'm still doing fine. I think my pdoc would only prescribe me an antidepressant if I ever dipped down into a deep depression, which is not really my usual mood tendency. I lean more towards hypomania and mixed states.
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Old 06-19-2016, 07:32 PM #5
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Default Re: SSRI induced mania/psychosis. Have you had it?

I've had what I now know to be mania induced from SSRI's a few times. At the time, I didn't know I was manic, just thought I was cured. I ran around doing crazy things with my mouth flapping away with rapid speech but had no idea it was mania or bad. I thought the depression was gone and I was happy. Paxil and welbutrin both did this. Prozac had me manic and angry and I told my doctor but this was when it first hit the market and doctors didn't know manic response could happen from SSRI's or at least my doc didn't know. No psychosis from SSRI's that I'm aware of..... I do that part all on my own I guess.

I'm so sorry all that happened to you. I bet your doctor didn't even warn you when he prescribed the meds. They should tell everyone who takes these meds to be watchful. That would be the responsible way to prescribe. Big hugs to you.
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Old 06-19-2016, 08:10 PM #6
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Default Re: SSRI induced mania/psychosis. Have you had it?

I have gone manic from zoloft once, wellbutrin twice, (the second time I was on lamictal too, just wasn't strong enough to keep me stable)...paxil without a mood stabilizer pushed me into a manic state (before my diagnosis, but led to my eventual diagnosis, I had two manic and two depressed episodes in one year) and then a new pdoc added prozac to the effexor I was already taking and I soared into the sky (then went mixed, oh my gosh)...that was the year I went to the hospital for the first time ever. effexor was the only snri that I was ever able to take, along with a mood stabilizer, that kept me ok. I have had SO many med changes over the years depending on what mood I end up in, I typically had two episodes a year for several years. I"m prescribed pristiq now but am trying to get my meds back under control...I was not taking them for about 2 months. and no, not for any good reason, I was just being lazy and stubborn.
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Old 06-19-2016, 08:51 PM #7
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Default Re: SSRI induced mania/psychosis. Have you had it?

In retrospect my worst manias occurred when I was on Zoloft. I didn't know I was bipolar and my primary care doc kept putting me on antidepressants and I'd often quit taking them during or after what I realize how was a manic episode. Most recently an ER psychiatrist took my off of Cymbalta and believes it had a hand in kicking off my current mania.
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Old 06-19-2016, 09:12 PM #8
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Default Re: SSRI induced mania/psychosis. Have you had it?

not an ssri but remeron did it to me
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Old 06-19-2016, 09:28 PM #9
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Default Re: SSRI induced mania/psychosis. Have you had it?

The only AD I've been on is sertraline. It made me pleasantly hypo/manic for a few days, than made me crash for a few days. Up and down and up and down. It was awful. I ended up in the hospital. No psychosis though.
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Old 06-19-2016, 10:20 PM #10
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Default Re: SSRI induced mania/psychosis. Have you had it?

Before I was diagnosed (and had seen a pdoc) Wellbutrin sent me into a very fun hypomania until I started seeing things. It was prescribed under a different name (can't remember which) by my PCP for smoking cessation.
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