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Symbyax (olanzapine and fluoxetine HCl)

Overall Rating


*** 1/2
(Out of 5 Stars)
Side Effects
Average Price: $65.00 Thumbs up Recommended By
83% of reviewers (of 6 reviews)
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Generic Name: Olanzapine and fluoxetine HCl capsules oh-LAN-za-peen & floo-OX-e-teen HCI

Drug Class: Fluoxetine and Olanzapine




This medicine is a combination drug used to treat bipolar disorder. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine exactly as directed. This medicine is taken orally once every evening. This medicine may be taken with food if stomach upset occurs.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • All medicines may cause side effects in some patients. Serious side effects reported by patients treated with SYMBYAX follow below:
    • Severe allergic reactions that cause hives, swelling of your face, eyes, mouth, or tongue, trouble breathing or a rash with fever and joint pain. Tell your doctor right away if you get these symptoms. Your doctor may stop SYMBYAX and prescribe medicines t
    • Strokes and "mini-strokes" called transient ischemic attacks (TIAs). These are more common in elderly patients with dementia. As with other mental health drugs, SYMBYAX should be used with caution in elderly patients with dementia. SYMBYAX is not approved
    • High blood sugar or diabetes. Patients who already have diabetes should have their blood sugar checked regularly during treatment with SYMBYAX. Patients at risk for diabetes (for example, those who are overweight or have a family history of diabetes) who
    • Neuroleptic malignant syndrome (NMS). NMS is a rare, but life-threatening reaction to certain medicines for mental problems, including SYMBYAX. Stop taking SYMBYAX and call your doctor right away if you get any of the following symptoms of NMS, such as a
    • Tardive dyskinesia. This is a condition caused by certain medicines for mental problems, including SYMBYAX. It causes body movements, mostly in your face or tongue, that keep happening and that you cannot control. It may start after you stop taking SYMBYA
    • Low blood pressure. SYMBYAX may cause low blood pressure in some patients. Low blood pressure is more likely in patients who have heart problems, who have brain problems such as strokes, who take certain medicines, or who drink alcohol. Signs of low blood
    • Seizures. SYMBYAX should be used cautiously in people who have had seizures in the past or who have conditions that increase their risk for seizures.
    • Impaired judgment, thinking, and motor skills
    • Trouble swallowing
    • Abnormal bleeding. When SYMBYAX is used alone, and especially with certain other medicines that can increase bleeding risk (for example; ibuprofen or aspirin), your risk of bleeding can increase. If you notice increased or unusual bruising or other bleedi
    • Low salt levels in the blood. SYMBYAX can cause a low salt level in the blood. Weakness, confusion, or trouble thinking can be caused by low salt levels in the blood. If you develop any of these symptoms, contact your doctor.
    • Body temperature problems. SYMBYAX can cause problems in keeping your body temperature regular. Do not become overheated or dehydrated during hot weather or exercise, or when using a hot tub.
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    • Tell your doctor if you are allergic to fluoxetine or olanzapine.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Do not get over-heated or dehydrated (loss of body fluids) while taking this medicine.
    • Do not take a MAOI medicine for at least 5 weeks after stopping this medicine.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Before taking any prescription or over-the-counter medications, supplements, or herbal products with this medicine, talk to your doctor about possible interactions.

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Before taking this medicine, if you are pregnant, breastfeeding or planning to become pregnant, talk to your health care provider. This medicine is not recommended for nursing mothers.
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More Information

For more information about this medicine, talk to your healthcare provider.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:

  On 8 Aug 2006

  By John M. Grohol, Psy.D.







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New Member

Registered: September 2015
Location: Canada
Posts: 8
Fri January 18, 2019 Recommended? Yes | Total Spent: None indicated| Rating: 8 

PROS: I don’t notice anything negative in the soup I take.
CONS: None

I’m not sure what it does for me.

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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I frequently purchase prescribed medicines by using americantrustpills (seriously, this place sucks) without danger. The fact is that I use to take tons of it so minimal price tag is extremely important for me.

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Grand Poohbah

Registered: March 2008
Posts: 1983
Sun November 18, 2012 Recommended? Yes | Total Spent: $65.00| Rating: 10 

PROS: Remission of my bipolar symptoms!
CONS: mild weight gain from the Zyprexa component

Symbyax has literally been a miracle drug for me. I've tried multiple drugs and combinations, all of which worked to some extent, none of which completely controlled my symptoms. I thought that I was just doomed to live with a certain level of depression, despite being on meds. Symbyax for me is proof that you don't have to settle. I have had almost no depressive symptoms for the past 2.5 months that I have been on it. I'm more confident. I have more friends. I'm not just not suicidal; I actually celebrate being alive. I've gained about 10 Ibs on this med; that is okay with me because I lost 10 lbs from depression last spring, so I'm pretty much right where I was before. I can't guarantee that you will have such an excellent experience with Symbyax because everyone responds to drugs differently, but it's definitely worth a try.

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Newly Joined

Registered: December 2008
Sat December 20, 2008 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: none
CONS: excessive sleep and weight gain

I am bipolar II and my doc prescribed 6mg/25mg along with doxepin and buspar. I slept ALL the time. I could not get out of bed so he dropped me down to 3mg/25mg. I was still sleeping all of the time which caused me to drop out of school and I was always craving sweets which I have never done before. All I did was sleep and eat ice cream and chocolate. I gained 15lbs in one month. It was horrible. I couldn't function. I stayed in bed for a whole week. I cannot recommend it.

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Newly Joined

Registered: December 2007
Location: South Carolina
Sun December 23, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 10 

PROS: Anxiety gone in 3 days!
CONS: Severe sedation at first, weight gain

I started taking Symbyax 3mg/25mg for PMDD, Depression, and somewhat Bipolar Disorder. The first night I took it I became EXTREMELY tired and I did feel like a zombie for the entire next day, but the next night I was less tired and the next day I felt great. I did start drinking 1 cup of coffee in the morning to wake up a bit more for the day. I have gained about 5 pounds already, but that's OK for now because I was underweight from taking Prozac by itself before. I noticed that I do get really hungry at night and look for sweets. I have figured out that if the sweets are not in the house than I can't eat them when I get cravings. This medication has almost completely ended my anxiety and I feel much better already. I am extremely sensitive to side effects and I feel that this medication is great for people that have that problem. Just give it a few good days and the sedation lifts a great deal, and there is absolutely no nausea or other bothersome side effects.

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Registered: September 2006
Posts: 5677
Tue September 25, 2007 Recommended? Yes | Total Spent: None indicated| Rating: 8 

PROS: treats many symptoms of bipolar illness
CONS: makes one sleepy and restless, very very expensive

This drug is great for bipolar with psychotic features. I had to start taking it at night due to excessive sleepiness. This drug is very very expensive, and my insurance is no longer covering the cost.

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