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Imipramine (Tofranil)

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** 1/2
(Out of 5 Stars)
Side Effects
Average Price: $3.00 Thumbs up Recommended By
88% of reviewers (of 8 reviews)
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Generic Name: Imipramine im-IP-ra-meen

Drug Class: Antidepressants, tricyclic




This medication is used for short-term treatment of various forms of depression and for chronic neuropathic pain (nerve pain) or to prevent migraine headaches. Your doctor may prescribe this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Take this medicine as directed by your physician. Amitriptyline is taken orally and can be taken with or without food. Dosing varies widely with this medicine depending on the condition that it is being prescribed for. Do not stop taking this medicine abruptly without consulting with your doctor.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
    • An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing.
    • Some common side effects reported with this medicine include:
      • drowsiness or dizziness
      • dry mouth
      • constipation
      • nausea
      • blurred vision
      • headache
      • weight gain
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    • Elderly patients generally should avoid it because this medicine due to an increase in dizziness resulting in falls.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Talk with your physician or pharmacist if you are taking other medications.
    • Possible drug interactions may occur with this medicine and:
      • Phenobarbital
      • MAO inhibitors (severe)

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For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.
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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:

  On 8 Aug 2006

  By John M. Grohol, Psy.D.







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Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I normally get prescribed medications by americantrustpills (seriously, this place sucks) free of danger. Unfortunately I use to take lots of it so minimal price tag is pretty important for me.

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Registered: January 2014
Location: ...
Posts: 229
Sun January 19, 2014 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: none
CONS: debilitating side effects


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Grand Member

Registered: July 2011
Location: Canada
Posts: 886
Tue August 30, 2011 Recommended? Yes | Total Spent: $2.00| Rating: 8 

PROS: Good anti-depressant
CONS: Can cause mania

I took this med from 1987-1994, and asked my Dr. to prescribe it again in 2011. The SSRI's and SNRI's don't work as well for me as Imipramine.

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New Member

Registered: March 2008
Location: Oregon
Posts: 5
Fri March 21, 2008 Recommended? Yes | Total Spent: None indicated| Rating: 7 

PROS: few side affects
CONS: dry mouth, constipation

Been taking it off and on for 30 years. It helps with depression but ruined my teeth from dry mouth. It didn't make me more suicidal like the newer ones.

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Sun September 24, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 5 

PROS: helped with the depression for awhile (induced hypo mania?)
CONS: dry mouth, "pooped out" & needed to keep increasing dosage

This was before I was diagnosed with bipolar so it probably wasn't the right drug for me.

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Legendary Wise Elder

Registered: October 2004
Location: Kentucky, USA
Posts: 21785
Thu September 14, 2006 Recommended? Yes | Total Spent: $4.00| Rating: 8 

PROS: no bad side effects
CONS: caused extreme dry mouth

Seemed to have no effect on my depression. The dry mouth was a problem because of my professional flute playing at the time. It was impossible to play my flute with that dry of a mouth. Since it wasn't having any effect (positive or negative) on my depression, it seemed like stopping this medication was the best idea.

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Wed September 13, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 5 

CONS: drowsiness

It did not work for me and made me very drowsy, but some of my friends are very happy with it.

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Tue September 12, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 1 


I had very few side effects - mainly felt like I was moving in slow motion and a bit foggy. I was on it for headaches and depression. it brought my depression into neitral where I neither felt sad or happy. as for headaches - didn't help. And with no wonder - I now know I have DID. there is no medication that will take away headaches due to switching personalities. though it didnt do much for me I am leaving the recommendation at yes because one persons flop medication can be another persons miracle drug.

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