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Old 08-31-2018, 07:05 AM   #21
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Default Re: AP Switching: Aripiprozole to Quetiapine

It is always a pleasure to help. I read up on all these things on any case, so may as well discuss it amongst you people.

That hyper-focus on one specific thing, as well as the agitation being displayed whilst repeating the action, may both be the symptoms of AS. They are actually symptoms of AS.
So yes, stimming.

Yes, the rigidity and change causing distsress are both other symptoms of AS. These things are definitely something that can cause agitation.
Ah, now that I think of it! Some of that agitation may likely be caused be things like an unexpected night out to a restaurant, for example. It can be extremely distressing.

So no sudden shift may indicate that it is the AS, though a doctor would be able to say for sure.

Hope this helps!
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Old 08-31-2018, 07:13 AM   #22
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Default Re: AP Switching: Aripiprozole to Quetiapine

hi. risperidone is good for some people. not a big fan myself, but i think it may have been because i had to take in a hospital, so i associate(d) it with the more draconian elements of psychiatry. anyway...

try to press to get his prolactin levels check, frequently. i think elevated prolactin can be treated with an additional drug (what fun! LOL), but left untreated...bad stuff happens.

keep an eye out for EPS, TD. Risperidone can be fairly tolerable, but EPS and TD seem to be more of an issue with risperidone than with some other options, but...as long as the dose is kept low(ish), its probably better than an older tranquilizer (by lowish, I think I mean 4mgs or so...after that, EPS comes out in force, in big studies).

Other than that...

I just hope some sort of treatment ends helping, long term. sometimes, when i had more severe problems...my shrink would prescribe a 2nd tranquilizer to take on top of the daily one. so...20mgs/abilify, plus a low dose or risperidone to take if needed. that way, i could usually stay on the lower dose of daily tranq, and then still get the as needed tranq for when i was agitated. just a thought.
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Old 08-31-2018, 08:44 AM   #23
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Default Re: AP Switching: Aripiprozole to Quetiapine

Geodon has worked great for my agitation (with some side effects). I passed out on Abilify and side effects on Seroquel.
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Old 09-01-2018, 06:52 PM   #24
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Default Re: AP Switching: Aripiprozole to Quetiapine

Quote:
Originally Posted by still_crazy View Post
hi. risperidone is good for some people. not a big fan myself, but i think it may have been because i had to take in a hospital, so i associate(d) it with the more draconian elements of psychiatry. anyway...

try to press to get his prolactin levels check, frequently. i think elevated prolactin can be treated with an additional drug (what fun! LOL), but left untreated...bad stuff happens.

Ja, I've heard some of the stories.


Quote:
Originally Posted by still_crazy View Post
keep an eye out for EPS, TD. Risperidone can be fairly tolerable, but EPS and TD seem to be more of an issue with risperidone than with some other options, but...as long as the dose is kept low(ish), its probably better than an older tranquilizer (by lowish, I think I mean 4mgs or so...after that, EPS comes out in force, in big studies).

One of the problems is that my son has had compulsive tics on and off since he was 6 or so - which was long before he began taking psychotropic meds and their resurfacing/worsening seems independent of him not being on meds, though I know some of them make it worse and since he has been on Rispiridone, they have worsened noticeably. Giving Benadryl seems to help some.


Quote:
as long as the dose is kept low(ish),... (by lowish, I think I mean 4mgs or so...after that, EPS comes out in force, in big studies).
Really? hmmm...when we first had him on the Rispiridone (0.5mg 2X/day), we saw a noticeable improvement in his anger and more so, we noted that his opposition/incredible stubbornness about everything had opened up - which is something we never saw with Abilify or anything else. This improvement lasted maybe...2 or 3 days max before we started to see the improvement subside and reverse.

We were going to ask for an increase...my concern being he may be more susceptible to EPS, with his given transient or compulsive tic disorder (I thought Rispiridone was supposed to help with OCD, right? Which is related to compulsive tics)

I just hope some sort of treatment ends helping, long term. sometimes, when i had more severe problems...my shrink would prescribe a 2nd tranquilizer to take on top of the daily one. so...20mgs/abilify, plus a low dose or risperidone to take if needed. that way, i could usually stay on the lower dose of daily tranq, and then still get the as needed tranq for when i was agitated. just a thought.[/QUOTE]


So, by taking the Rispiridone, you were able to stay low on the Rispiridone? In our son's case, the Abilify helped (first year and 3/4 anyway) with his bad irritation but it made his mania/perseverance worse and seemed to do something to his executive function - not sure if we would want to go that route but ... not at least until we know if the Risp. is going to help at any dose.


Thanks a bunch!


Quote:
Originally Posted by cool09 View Post
Geodon has worked great for my agitation (with some side effects). I passed out on Abilify and side effects on Seroquel.

When we switched from Abilify to Seroquel, there was a tapering period where he was on both, recall the pharmacists being quite concerned with that.


Thanks for the Geodon tip!



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Old 09-02-2018, 07:02 PM   #25
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Default Re: AP Switching: Aripiprozole to Quetiapine

I have PDD-NOS and for me mixing an atypical anti-psychotic and a mood stabilizer has worked best. Currently taking Geodon 100 mg (40 mg AM, 60 mg PM) and Lamictal XR 75 mg and its helping. I've taken Seroquel and Abilify in the past, Seroquel worked better than Abilify, I only went off it due to weight gain. Abilify did give me Tardive Dyskensia at one point so that's why I went off that.
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Old 09-03-2018, 06:18 PM   #26
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Default Re: AP Switching: Aripiprozole to Quetiapine

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Originally Posted by 88Butterfly88 View Post
I have PDD-NOS and for me mixing an atypical anti-psychotic and a mood stabilizer has worked best. Currently taking Geodon 100 mg (40 mg AM, 60 mg PM) and Lamictal XR 75 mg and its helping. I've taken Seroquel and Abilify in the past, Seroquel worked better than Abilify, I only went off it due to weight gain. Abilify did give me Tardive Dyskensia at one point so that's why I went off that.

Is Lamictal in the same class of compounds (antiseizure) that Gabapentin is in? I remember, it seems, that DS' PsyMD had said they (Gabapentin, etc) do not work with well with AS. Maybe I misheard.


There are ALOT of questions I've regarding PDD-NOS. I've not found too many keen on discussion (maybe I haven't asked the right questions at the right time, though)


Maybe you could keep a spot on for them as I manage to post them here and there in the Austism forum, if you're a mind to.


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Last edited by DahveyJonez; 09-03-2018 at 06:19 PM.. Reason: Typo
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Old 09-03-2018, 07:34 PM   #27
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Default Re: AP Switching: Aripiprozole to Quetiapine

Lamictal was a wonder med for me. Unfortunately I did develop SJS and had to stop taking it. Autistic people with family with autoimmune illness should probably not take this med, and if the patient himself has any autoimmunities, they should absolutely not take Lamictal. They did not know this when I tried it. Too bad. It wasn't like gabapentin or anything like that for me.

If autism coexist with ADD/ADHD, a stimulant might help. Sometimes when they coexist, stimulants still don't help and can create problems. Different for different people.

Some people with autism tolerate neuroleptics quite well, but I seem to really need my dopamine. The only one in this class I tolerated at least a bit was Risperdal. The other ones, Seroquel, Geodon, made me feel like I was in HELL. Maan! It is hard to explain. I feel like the world is sometimes too close to me. Neuroleptics made me feel like I was even way closer to the world, and everything was hyper real. Like every impression, every thought, really got to me. Like I had no protection from anything. The world mentally scorched me.

Luckily I stopped having anger issues after getting on Luvox, sometimes other SSRIs can help as well. But all people don't have that kind of luck. It actually made me have a little more protection from the "world" but the med that helped most with that part was a benzo, and you don't give those to kids. About SSRIs, it is not like if you tried one you tried them all, I have tried several and all of them gave me different reactions.

My anger stemmed from everything being too close and getting to me. It is kind of hard to explain. I couldn't drop negative emotion, it just built up.

If he responds well to Benadryl, you could try the antihistamine path. Antihistamines are brutally sedative to me, even the non sedating ones. But we're all different. Antihistamines in psychiatric treatment are for example Vistaril, prometazine and doxylamine.

Personally SSRI+benzo dealt well with irritability and Ritalin made me less "autistic" even if they claim it makes autistic people more autistic. I was unhappy about being less though, so I just take it on rare occasions.
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Old 09-04-2018, 12:22 AM   #28
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Default Re: AP Switching: Aripiprozole to Quetiapine

Quote:
Originally Posted by -jimi- View Post
Lamictal was a wonder med for me. Unfortunately I did develop SJS and had to stop taking it. Autistic people with family with autoimmune illness should probably not take this med, and if the patient himself has any autoimmunities, they should absolutely not take Lamictal. They did not know this when I tried it. Too bad. It wasn't like gabapentin or anything like that for me.

Corr blind me - you developed Stevens Johnson?!? From what I've seen of photos and all - its absolutely horrid! Look like plane crash victims. Nightmares...


I think I mentioned it already to someone but we had DS tested for an allele of a gene that if present, indicated a much higher risk. As his mum was of Asian descent (also higher risk for SJS), one did not want to have this strand of DNA and take medicines that had a high incidence of triggering it.


No known autoimmune disorder, though there is a penicillin allergy and looks like it'd be wise to have him take allergy shots for environmental triggers as pet dander, pollen, dust and moulde, I'm uncertain if that would increase his risk.



Quote:

If autism coexist with ADD/ADHD, a stimulant might help. Sometimes when they coexist, stimulants still don't help and can create problems. Different for different people.
He does. In fact, he was screened early on for severe ADD (war screened for AS as well, but they didnt catch it) and has taken those on and off. Do see def improvement but it wears off and when it does...bad, bad, bad. Also aggravates his on/off transient compulsive tics.

Quote:
Some people with autism tolerate neuroleptics quite well, but I seem to really need my dopamine. The only one in this class I tolerated at least a bit was Risperdal. The other ones, Seroquel, Geodon, made me feel like I was in HELL. Maan! It is hard to explain. I feel like the world is sometimes too close to me. Neuroleptics made me feel like I was even way closer to the world, and everything was hyper real. Like every impression, every thought, really got to me. Like I had no protection from anything. The world mentally scorched me.

Luckily I stopped having anger issues after getting on Luvox, sometimes other SSRIs can help as well. But all people don't have that kind of luck. It actually made me have a little more protection from the "world" but the med that helped most with that part was a benzo, and you don't give those to kids. About SSRIs, it is not like if you tried one you tried them all, I have tried several and all of them gave me different reactions.

My anger stemmed from everything being too close and getting to me. It is kind of hard to explain. I couldn't drop negative emotion, it just built up.

If he responds well to Benadryl, you could try the antihistamine path. Antihistamines are brutally sedative to me, even the non sedating ones. But we're all different. Antihistamines in psychiatric treatment are for example Vistaril, prometazine and doxylamine.

Personally SSRI+benzo dealt well with irritability and Ritalin made me less "autistic" even if they claim it makes autistic people more autistic. I was unhappy about being less though, so I just take it on rare occasions.
I've much to add here - but they be screaming at me to get off the computer, already.


More later!


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You don't know what it's like to listen to your fears


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Some kind of solitude is measured out in you
You think you know me but you haven't got a clue
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Old 09-04-2018, 09:52 AM   #29
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Default Re: AP Switching: Aripiprozole to Quetiapine

Quote:
Originally Posted by DahveyJonez View Post
Is Lamictal in the same class of compounds (antiseizure) that Gabapentin is in? I remember, it seems, that DS' PsyMD had said they (Gabapentin, etc) do not work with well with AS. Maybe I misheard.


There are ALOT of questions I've regarding PDD-NOS. I've not found too many keen on discussion (maybe I haven't asked the right questions at the right time, though)


Maybe you could keep a spot on for them as I manage to post them here and there in the Austism forum, if you're a mind to.


Cheers,
Yes, Lamictal is also an anti-seizure med. I took Gabapentin for a few years and it helped me as well. For me Gabapentin was especially helpful because I have sensitive skin and one of the side effects is loss of feeling so it was actually a nice side effect for me. There is concern sometimes because of this though for a fear a child could cut their foot and not realize for example. Lamictal doesn't have the same loss of feeling effects though.

Sure, I'll keep an eye on the autism forum.
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Old 09-04-2018, 03:49 PM   #30
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Default Re: AP Switching: Aripiprozole to Quetiapine

Quote:
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Corr blind me - you developed Stevens Johnson?!? From what I've seen of photos and all - its absolutely horrid! Look like plane crash victims. Nightmares...
Everyone's case isn't as dramatic. I was more close to anaphylaxis than having a lot of skin involvement. The rash I had wasn't severe. They actually missed it at first because it didn't come with the rash first, it developed later. My main symptoms were high fever, very severe headache and body pain and very low blood pressure. I only had a rash on my arms and thighs that actually went away quite quickly and wasn't really bothersome, then I developed blisters in and around my mouth and they didn't stay for that long either.

Still the reaction could have lead to full anaphylaxis and death.
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