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Red face Feb 10, 2019 at 10:28 PM
  #1
I can't take any of the SSRI's (cause ocd and ptsd to go beserk) and many of the others can cause more liver damage to someone with cirrhosis like I have.

I have starting doing things to improve my mood like listening to a variety of music, cleaning, reading.

I don't know if there are any other antidepressants or mood elevators that may help me. I am on Gabapentin for nerve pain and it helps my mood a bit. Have tried Lamactil and got hives from it so it's out.

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Default Feb 10, 2019 at 10:31 PM
  #2
Have you tried Emsam? It's an MAOI so there are some restrictions but t is a patch so doesn't pass through your digestive system and so it's easier on your organs. It's also really effective in my experience (9 years and still doing well on it).

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Default Feb 10, 2019 at 11:04 PM
  #3
Try Wellbutrin

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Default Feb 11, 2019 at 01:47 AM
  #4
I might ask my psychiatrist for something other than an SSRI (Because they give me panic attacks and kill my focus).

I'll let you know what she recommends.
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Default Feb 11, 2019 at 05:28 AM
  #5
Quote:
Originally Posted by LucyD View Post
I can't take any of the SSRI's (cause ocd and ptsd to go beserk) and many of the others can cause more liver damage to someone with cirrhosis like I have.

I have starting doing things to improve my mood like listening to a variety of music, cleaning, reading.

I don't know if there are any other antidepressants or mood elevators that may help me. I am on Gabapentin for nerve pain and it helps my mood a bit. Have tried Lamactil and got hives from it so it's out.
What about an SNRI or Triclyclic? I take cymbalta which is an SNRI and I take lamictal as a mood stabilizer. Many people who have trouble with standard SSRI's take something else like cymbalta or lamictal.

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Default Feb 11, 2019 at 08:25 AM
  #6
Wellbutrin is an SNRI that worked well for me. I used the xl version (there are several types). I have PTSD also. The other nice thing about wellbutrin is that I found it not at all difficult to get off of when the time was right.
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Default Feb 11, 2019 at 03:13 PM
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Try Wellbutrin
Tried Wellbutrin and it makes me so nervous I can't stand it.

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Default Feb 11, 2019 at 03:15 PM
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What about an SNRI or Triclyclic? I take cymbalta which is an SNRI and I take lamictal as a mood stabilizer. Many people who have trouble with standard SSRI's take something else like cymbalta or lamictal.
Cymbalta can cause liver toxicity. Lamactil gave me hives.

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Default Feb 11, 2019 at 03:15 PM
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Wellbutrin is an SNRI that worked well for me. I used the xl version (there are several types). I have PTSD also. The other nice thing about wellbutrin is that I found it not at all difficult to get off of when the time was right.
Made me very very nervous. Can't take it.

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Default Feb 11, 2019 at 03:16 PM
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Have you tried Emsam? It's an MAOI so there are some restrictions but t is a patch so doesn't pass through your digestive system and so it's easier on your organs. It's also really effective in my experience (9 years and still doing well on it).
I haven't tried any MAOIs but will look into them.

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Default Feb 11, 2019 at 03:17 PM
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What about an SNRI or Triclyclic? I take cymbalta which is an SNRI and I take lamictal as a mood stabilizer. Many people who have trouble with standard SSRI's take something else like cymbalta or lamictal.
Not trying to be a downer but Tricyclics can cause heart problems.

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Default Feb 11, 2019 at 03:22 PM
  #12
Just found this on the research:

"Antidepressant-induced hepatotoxicity. ... Classical antidepressants such as monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants (TCAs) seem to have the highest potential to induce liver damage compared with the newer drugs such as selective serotonin re-uptake inhibitors (SSRIs)."

And basically from my prior research that is what I was saying in my first post.

Thanks you for all of your ideas.

I'm not really doing too bad without an antidepressant right now today. I get some real low points at times but maybe I can make it through them as I used to when I didn't take antidepressants before. I'm getting better at self-talk and getting through the negative thoughts I have with depression. Thanks again everyone.

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Default Feb 12, 2019 at 11:31 AM
  #13
maybe...could you see about an increase in the gabapentin? i take a low dose, as needed...not the best stuff ever, but it seems to brighten my mood when the low point hit.
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Default Feb 12, 2019 at 05:18 PM
  #14
Quote:
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I can't take any of the SSRI's (cause ocd and ptsd to go beserk) and many of the others can cause more liver damage to someone with cirrhosis like I have.

I have starting doing things to improve my mood like listening to a variety of music, cleaning, reading.

I don't know if there are any other antidepressants or mood elevators that may help me. I am on Gabapentin for nerve pain and it helps my mood a bit. Have tried Lamactil and got hives from it so it's out.
yeah Lucy- you know what i need for depression ? only its not depression anymore. its disgust for the all the pills i took and the doctors. but anyway what would make my life better is the millions of dollars i could have made if i was'nt discrimonated against from a disabilty. but no they chose to feed me pills for 10 years. and just sweep it under the rug. so to say. and how as i say about music. old classic r&r. the effect is better than pills. only the effect does'nt last as long. and bad co. says NA NA NA ANA NA NAAAA !
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Default Feb 12, 2019 at 08:03 PM
  #15
I know some doctors use stimulants in treatment resistant depression.

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Default Feb 12, 2019 at 08:03 PM
  #16
remeron is another anti depressant you can try.

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Default Feb 12, 2019 at 08:45 PM
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remeron is another anti depressant you can try.
Thank you to you all! I had tried them all including Remeron. Made me extremely sedated all the time and ate so much and gained weight. Have an eating disorder, too, so all in all that one's not too good for me.

I have been taking Gabapentin for nerve pain but it also is helping my mood somewhat so that's a plus. I will stick with it and tell my new psychiatric np how Gabapentin has been helping some and see what he says.

Music has been a great antidepressant for me and I highly recommend it. Also cleaning and organizing my apt. helps me feel better as I don't feel like a slob anymore...lol

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Default Feb 16, 2019 at 07:21 AM
  #18
Have you talked about it with a psychopharmacologist or an experienced psychiatrist?

There are some meds that can induce liver issues but that they are not more likely to cause them on people who already have some liver problems (like tianeptine that can be taken by alcoholics who had developed liver dysfunction even if tianeptine by itself can cause liver failure). Other meds are metabolized a lot by the liver so if your liver functions less than normal, it can be fixed by taken a lower dose.

Tricylic antidepressants damage yout heart when OD, on standard dosage they are not that dangerous. AP can cause heart probelms too (they prolonge QT interval and it may end up causing an arrhythmia).

Cardiovascular effects of therapeutic doses of tricyclic antidepressants. A review. - PubMed - NCBI

It's much more complex than a list of side effects...

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Default Feb 25, 2019 at 08:21 AM
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maybe...could you see about an increase in the gabapentin? i take a low dose, as needed...not the best stuff ever, but it seems to brighten my mood when the low point hit.
I told my psychiatric np that Gabapentin is helping me. My GP internist prescribed it for nerve pain last nov. So my pnp prescribed it for me on fri because I was out of refills. With the low dose of risperdal I'm taking, together they (ris. and gab.) are addressing and helping all my depression and anxiety problems. I feel relaxed, calm and pretty upbeat. Plus the Gabapentin does not stifle my emotions like antidepressants did to me. Not sayin they do that to everyone. It was my experience.

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Default Feb 25, 2019 at 08:27 AM
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Have you talked about it with a psychopharmacologist or an experienced psychiatrist?

There are some meds that can induce liver issues but that they are not more likely to cause them on people who already have some liver problems (like tianeptine that can be taken by alcoholics who had developed liver dysfunction even if tianeptine by itself can cause liver failure). Other meds are metabolized a lot by the liver so if your liver functions less than normal, it can be fixed by taken a lower dose.

Tricylic antidepressants damage yout heart when OD, on standard dosage they are not that dangerous. AP can cause heart probelms too (they prolonge QT interval and it may end up causing an arrhythmia).

Cardiovascular effects of therapeutic doses of tricyclic antidepressants. A review. - PubMed - NCBI

It's much more complex than a list of side effects...
Thanks for your feedback. I did not get all of my information from a list of side effects, psychiatrists have told me what some antidepressants can do, too. I read a lot of journal articles, too, for my information. Often, there are debates on various findings. Anyways, doesn't matter now..not going to take any more antidepressants because I am now taking Gabapentin for depression and anxiety as well as nerve pain. I feel much better on it than any antidepressant class med. I've been on. They all gave me nervousness, sexual dysfunction, stifling of emotions, sleep disturbances and then there were other effects I had, too, that I no longer have without them, thank God. So glad I was prescribed Gabapentin. I also am working on being more active, getting busier doing productive things, listening to music as a therapy, and am feeling much better as a result. All the best to you.

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