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Old 02-18-2019, 01:23 PM #1
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Default Lurasidone or agomelatine for depression?

Does anyone have any experience with either of these drugs for depression? I saw my new psychiatrist today and he has given me the choice between the two. I have tried many other antidepressants and combinations and nothing has worked so these are pretty much my only options (other than ECT).
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Old 02-18-2019, 03:36 PM #2
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Default Re: Lurasidone or agomelatine for depression?

They are very different, lurasidona is an AP with mood stabilizer properties, agomelatine is an atypical antidepressant that binds to melatonin receptors.

They side effects profile is also different.

Do you have any experience with AP?

Agomelatine is something different you won't find in any other med.
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Old 02-18-2019, 03:46 PM #3
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Default Re: Lurasidone or agomelatine for depression?

Yes, I have tried quetiapine and aripiprazole but had to stop because of the side effects.
I'm currently on moclobemide but it isn't helping. My previous psychiatrist thought I had pretty much exhausted all options but the new one thinks it is worth trying these two. Though that is mainly because the waiting list for therapy is so long that at least this will look like they are doing something to try to help me...
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Old 02-18-2019, 03:58 PM #4
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Default Re: Lurasidone or agomelatine for depression?

Quote:
Originally Posted by littleblackdog View Post
Yes, I have tried quetiapine and aripiprazole but had to stop because of the side effects.
I'm currently on moclobemide but it isn't helping. My previous psychiatrist thought I had pretty much exhausted all options but the new one thinks it is worth trying these two. Though that is mainly because the waiting list for therapy is so long that at least this will look like they are doing something to try to help me...

If I were you, considering the bad experience with quetiapine and aripiprazole, I would try agomelatine first.

What does your current psychiatrist think about it?
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Old 02-18-2019, 04:09 PM #5
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Default Re: Lurasidone or agomelatine for depression?

Quote:
Originally Posted by OliverB View Post
If I were you, considering the bad experience with quetiapine and aripiprazole, I would try agomelatine first.

What does your current psychiatrist think about it?
Current psychiatrist (who I saw for only the second time today) seems pretty disinterested (I think he is annoyed because I don't want ECT). He said it is up to me which one i want to try. If I go for agomelatine I will need blood tests first and am a little concerned about the risk of liver damage as I am obese but then the side-effects from the antipsychotics I tried before were pretty awful so I am kind of between a rock and a hard place...
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Old 02-19-2019, 03:34 AM #6
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Default Re: Lurasidone or agomelatine for depression?

Quote:
Originally Posted by littleblackdog View Post
Current psychiatrist (who I saw for only the second time today) seems pretty disinterested (I think he is annoyed because I don't want ECT). He said it is up to me which one i want to try. If I go for agomelatine I will need blood tests first and am a little concerned about the risk of liver damage as I am obese but then the side-effects from the antipsychotics I tried before were pretty awful so I am kind of between a rock and a hard place...
Lurasidone is considered by some as a weigth neutral AP, and according to this article, it doesn't mess up with carb or lipids metabolism:

Lurasidone: a clinical overview. - PubMed - NCBI

If you are worried about sedation and similar side effects, since AP tends to work quicker than AD, there is the possibility of trying the AP first, see how it goes, and if it doesn't work then try the AD.


Anyway, as far as I have found here:


Agomelatine liver damage usually is reversible:

A systematic review of agomelatine-induced liver injury

(Most of AD has some liver damage risk)


May I ask you why your pdoc wants you to try ETC before exhausting all pharmacological posibilities?
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Last edited by OliverB; 02-19-2019 at 03:48 AM.
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Old 02-24-2019, 06:34 AM #7
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Default Re: Lurasidone or agomelatine for depression?

I have been taking valdoxen (aglomelatine) for a few months now, my psychiatrist added it alongside my 100mg pristiq, rather than increasing my pristiq dose. I am finding it really good, honestly, despite the expense. I have had no side effects that I know of (unlike the pristiq) and my liver function tests have all been fine. I am falling asleep soooo much faster, and no longer have to sedate myself with other drugs (which would often leave me feeling drowsy in the morning)
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