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Legendary Wise Elder
Member Since Jul 2018
Location: CA
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Sep 11, 2019 at 05:25 PM
#1
My Pdoc told me to take SAM-E in conjunction with my anti-depressant (Trintellix), ADHD medication (Vyvanse), and anti-psychotic (Rexulti). Does anyone have experience with SAM-E? Does it work? Side effects? It's OTC but that doesn't necessarily mean it's safe.
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Magnate
Member Since Apr 2016
Location: North America
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Sep 11, 2019 at 08:21 PM
#2
I tried a bottle of it a few years ago. For me, it didn't seem to make a difference, but I only took it for about a month. I didn't have any side effects.
I wonder if its effectiveness all depends on your body chemistry. |
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Grand Member
Member Since Sep 2014
Location: USA
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Sep 11, 2019 at 08:38 PM
#3
Yes! It’s involved in the methylation pathway. Certain genetic mutations like the MTHFR mutation can disrupt the methylation process. The process is needed to make SAMe which is then used to make certain “happy” neurotransmitters like serotonin and dopamine. An oral SAMe supplement bypasses the dysfunctional part of the pathway. It has helped improve my sleep, but probably not my mood. It has helped improve the mood of others, though. It also seems to have affected my TSH binding (hypoactive thyroid), so I can decrease my thyroid medication now.
__________________ "I think I'm a hypochondriac. I sure hope so, otherwise I'm just about to die." PTSD OCD Anxiety Major Depressive Disorder (Severe & Recurrent) |
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Legendary Wise Elder
Member Since Jul 2018
Location: CA
Posts: 27,329
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Sep 12, 2019 at 12:56 PM
#4
Thank you. Yes my doctor is concerned about the MTHFR mutation for me. That is why he is recommending me take it. I haven't noticed any difference yet, or any side effects but it's only been two days.
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Grand Member
Member Since Sep 2014
Location: USA
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Sep 12, 2019 at 10:17 PM
#5
Most pdocs don’t know about this. I’m glad yours is well informed.
__________________ "I think I'm a hypochondriac. I sure hope so, otherwise I'm just about to die." PTSD OCD Anxiety Major Depressive Disorder (Severe & Recurrent) |
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