Subutex???

Calla lily12 · Oct 18, 2019 at 08:51 AM

Has anyone been prescribed this for treatment resistant depression? It may come under other names, but I don't know them. I'd be interested in hearing any experiences, good or bad.

sarahsweets · Oct 18, 2019 at 09:01 AM

Hey @Calla lily12 Here is something interesting I found:

Quote:

The Psychiatry Advisor take:
Buprenorphine, a medication used in the treatment of opioid addiction, may also benefit patients with treatment-resistant depression, who have not responded to antidepressants, researchers found.

Jordan F. Karp, MD, of the University of Pittsburgh School of Medicine in Pennsylvania, and colleagues assessed whether buprenorphine improved symptoms in 50 patients with treatment-resistant depression (TRD aged 50 years and older. Participants were prescribed titrated doses of buprenorphine (0.2–1.6 mg/d) during an eight-week period.

Changes in depression, anxiety, sleep, positive and negative effect, and quality of life were assessed. The Montgomery-Asberg Depression Rating Scale (MADRS) served as the main outcome measure.

Mean depression score (MADRS) at baseline was 27.0 versus 9.5 at week eight. A sharp decline in depression severity occurred during the first three weeks of buprenorphine exposure (mean change = −15.0), the researchers reported in the Journal of Clinical Psychiatry.

In addition, depression-specific items measuring pessimism and sadness indicated improvement during exposure, supporting a true antidepressant effect. Also, executive function and learning improved during treatment.

“Low-dose buprenorphine may be a novel-mechanism medication that provides a rapid and sustained improvement for older adults with TRD,” the researchers concluded.

Buprenorphine Improved Resistant Depression Outcomes - Psychiatry Advisor

Quote:

Originally Posted by Calla lily12

Has anyone been prescribed this for treatment resistant depression? It may come under other names, but I don't know them. I'd be interested in hearing any experiences, good or bad.

bpcyclist · Oct 18, 2019 at 08:46 PM

I was on it for a little over a year. I don't think it did much for me, but this was at a time when I was unbelievably sick and quite unstable.

Jolisse · Oct 23, 2019 at 10:08 AM

I take Suboxone for anxiety/depression and it has really helped me.

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Calla lily12 Grand Member Member Since Jul 2018 Location: a place far away Posts: 830 5 979 hugs given	Oct 18, 2019 at 08:51 AM #1 Has anyone been prescribed this for treatment resistant depression? It may come under other names, but I don't know them. I'd be interested in hearing any experiences, good or bad. __________________ Once you are real, you can't become unreal again. It lasts for always....
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bpcyclist Legendary Member Since Sep 2019 Location: Portland Posts: 12,681 (SuperPoster!) 4 40.2k hugs given	Oct 18, 2019 at 08:46 PM #3 I was on it for a little over a year. I don't think it did much for me, but this was at a time when I was unbelievably sick and quite unstable. __________________ When I was a kid, my parents moved a lot, but I always found them--Rodney Dangerfield
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Jolisse Grand Poohbah Member Since Jan 2013 Location: USA Posts: 1,853 11 58 hugs given	Oct 23, 2019 at 10:08 AM #4 I take Suboxone for anxiety/depression and it has really helped me.
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