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Junior Member
Member Since Jul 2010
Posts: 11
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May 29, 2020 at 11:30 AM
#1
Just recently had a relapse for 1st time in 10 years. I've seen some promising literature about Pharmacogenomics Testing related to a person's reaction to various AD meds.
Has anyone tried this recently? Is it helpful in any way or a waste of time? |
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 bpcyclist
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Member
Member Since Mar 2015
Location: Minnesota, USA
Posts: 82
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May 29, 2020 at 09:16 PM
#2
I'm really treatment resistant, so I did this hoping that it would give my doctors better insight to what types of medications would help me. Sadly, the results gave us nothing. It said that all the meds that did nothing should have worked. Meh.
But I have had friends who are not treatment resistant do it and they found the information helpful. __________________ "Everybody is a genius. But if you judge a fish by its ability to climb a tree, it will live its whole life believing that it is stupid." Albert Einstein |
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Junior Member
Member Since Jul 2010
Posts: 11
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May 30, 2020 at 12:42 PM
#3
Thanks for your input tree7car. Based on the past 20+ years with meds(mostly SSNRI's), I think that my body doesn't react 'well' to SSRI's(Prozac, Zoloft, Lexapro), but then again during my last bad episode 10 years ago, I tried Cymbalta(SSNRI) for the first time and my recollection is that I gave it 6+ weeks with no response and then reverted back to Effexor/Ven with good results again for the most part.
I was hoping that these kinds of new Testing procedures, that I only just found out about, might allow more 'precision', but maybe not? |
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Member
Member Since Mar 2015
Location: Minnesota, USA
Posts: 82
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May 30, 2020 at 09:50 PM
#4
It might differ depending on the company you use. Idk. I used GeneSight. I they have an example results sheet that show what type of information that they can offer you and your providers. Check it out.
 It might give you a better idea of what you get and see if it's worth your money.
__________________ "Everybody is a genius. But if you judge a fish by its ability to climb a tree, it will live its whole life believing that it is stupid." Albert Einstein |
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bpcyclist, MDDguy
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Jun 02, 2020 at 09:15 PM
#5
To me, where we are now, it is not really about genetic details of our specific illness features. The real issue is that there are not even remotely enough good ADs on the market. There are only 2 that hve ever worked wortha sh** for me, including MAOIs. We just don't have good options. Ketamine is a nice potential advancement for some, but in my opinion, the doses currently used are too low for some patients to respond to. I did well on a competitor to ketamine not available in the US, but side effects were severe (hypertension, among other things) and had to stop it.
In my opinion, glutamate research is the current best hope for many of us. __________________ When I was a kid, my parents moved a lot, but I always found them--Rodney Dangerfield |
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Junior Member
Member Since Jul 2010
Posts: 11
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Jun 04, 2020 at 08:00 AM
#6
Excellent observations bpcyclist.
Again, I am just recently trying to investigate because I have kind of had my head in the sand for most of the last 10 years while somewhat stable with Venlafaxine. As I mentioned in another Post, with the help of an 'Alternative Psychiatrist', I did try to wean off of VEN altogether with the help of alot of natural supplementation, but it got very ugly for me, so now I am titrating back up with VEN after 2 short bouts with Prozac and Zoloft. Hence why I am now curious about SSRI's NOT ever being an option for me(?). Thanks for your input! |
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Legendary
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Jun 04, 2020 at 11:18 AM
#7
Quote:
__________________ When I was a kid, my parents moved a lot, but I always found them--Rodney Dangerfield |
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Junior Member
Member Since Jul 2010
Posts: 11
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Jun 06, 2020 at 10:44 AM
#8
In hindsight, I guess I never should have tried to wean off of the VEN completely. Didn't see this coming! Now it's like starting all over again. Just desperately hoping that I can get back to the 'normalcy' I had for years before weaning down. I wish there was more precision with all of this stuff!
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