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Old 09-26-2020, 11:45 AM   #1
Rosepetal99
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Default Augmenting antidepressants with mood stabilizers/antipsychotic meds

Iím pretty sure I have treatment resistant depression because Iíve failed so many antidepressants, but Iíve heard that many psychiatrists augment antidepressants with mood stabilizers or antipsychotic medications. Iím not sure exactly why they do that and the prospect scares me a little, but has anyone here had success with that strategy?
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Old 09-26-2020, 01:19 PM   #2
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

My wife and I both are on what you are discussing and they keep both of us level, but thatís us. We have minimal side effects luckily, but I canít guarantee that. It effects everyone differently. I hope this helps.
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Old 09-27-2020, 04:53 AM   #3
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

I take an anti-psychotic, Risperidone, to augment my anti-depressant.


I had some weird side effects initially, but they mostly went away with time, and now I feel like the combination is really working.

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Old 09-27-2020, 09:31 AM   #4
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

Antipsychotics can definitely be used to augment antidepressants. There are many antipsychotics that are good for mood stabilization.

Personally, I was on Wellbutrin and Lamictal for mood stabilization (Bipolar Disorder) and was still feeling significant depression. My PA at the time prescribed Latuda, which is the first antipsychotic I've ever been on, and it did wonders to help my depression.

If you're hesitant, it's good to talk with your doctor about the options and why they are thinking a certain medication. There is good evidence that augmenting can help. Antipsychotics are not without risks, though, so you want to make sure you go in fully informed.
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Old 09-28-2020, 10:21 AM   #5
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

I have schizoaffective disorder so I am on an AP. I take Rexulti. It caused significant weight gain but I stayed on it because its the only thing that has helped. But literally I gained like
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I also take Trintellix and Cymbalta and Vyvanse and Xanax.
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Old 10-13-2020, 07:38 AM   #6
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

I take Abilify as well as Lexapro for depression. It helps, whereas the antidepressant alone does not work for me personally.
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Old 10-15-2020, 06:48 AM   #7
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

Personally with BPII I feel like both are necessary. One for the depression and one for the mood stabilization. Anti-psych's can be used for mood stabilization also.
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Old 10-16-2020, 01:29 AM   #8
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

Quetiapine works on low mood as well as other bipolar symptoms. I would not go for Risperidone or Aripiprazole. Olanzapine is very sedating, avoid. Lithium is a salt, avoid. A lot of people seem to have success with Amisulpride and Lamictal.
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Old 10-17-2020, 03:27 PM   #9
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Default Re: Augmenting antidepressants with mood stabilizers/antipsychotic meds

Like what's been said already , it really does depend on what works for you and your diagnosis. But if you haven't responded to AD's then definitely try AP's, that's my advice. I already said this in another post so I don't want to sound like someone that's preaching this but if you are MDD, or I call it unipolar depression, figure out which symptom is your main depressive symptom, sadness or anhedonia. That's according to this, not me: "At least five symptoms must occur for a DSM diagnosis of major depressive disorder (MDD), one of which must be sadness or anhedonia." PMC3688280

Just my opinion! But you shouldn't have to even guess which one, I most definitely didn't. If you don't have MDD, then you might need to disregard what I said above as that might need a different approach as far as meds.
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