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Nardil (phenelzine)

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Average Price: $60.00 Thumbs up Recommended By
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Generic Name: Phenelzine FEN-el-zeen

Drug Class: Antidepressants, miscellaneous




This medicine is used for treatment of depression. Your doctor may have prescribed this medicine to help relieve, anxiety, tension or to help you sleep. Your doctor may have prescribed this medicine for other conditions as well.
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General Information
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your healthcare provider. 

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Proper use of this medicine
Follow the directions given to by your doctor. This medicine should be taken orally on a regular basis. It is best that that you take this medicine at bedtime unless otherwise directed by your doctor. The extended-release tablet and capsule should be swallowed whole. Do not chew, divide, or crush the extended-release tablet or capsule.
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Missed Dose
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.
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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed.
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Possible Side Effects
    • dizziness, drowsiness
    • agitation, confusion
    • Consult your doctor immediately if you experience prolonged and painful erections.
    • Expected side effects are increased appetite and weight gain.
    • drowsiness, fatigue, dizziness
    • dry mouth
    • Unreported side effects are possible, talk to your healthcare provider if any other symptoms occur.
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    • Do NOT stop taking this medicine abruptly.
    • This medicine may cause dizziness or drowsiness.
    • Alcoholic beverages can increase the effects of this medicine and should be avoided.
    • Don't drive or perform other tasks that require concentration, until you know how this medicine affects you.
    • This medicine can increase the risk of suicidal thinking and behavior in some children and teens. Parents of children taking antidepressants should watch for signs of worsening depression or unusual changes in behavior.
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Seek medical attention immediately. U.S. residents can call the national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
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Drug Interactions
    • Before taking any new prescription or over-the-counter medication, talk to your doctor or pharmacist.
      Taking this medicine together with diazepam (Valium) may impair movement ability.
      Avoid using this medicine with MAO inhibitors. Your doctor or pharmacist can tell you if you are taking an MAO inhibitor.
    • Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin or azithromycin. This medicine should not be taken with MAO inhibitors.
    • Let your doctor know if you are taking any vitamin supplements or herbal products. St. John’s Wort should be avoided while taking fluvoxamine due to the increased side effects of too much serotonin.
    • MAO inhibitors should not be taken while taking the following drugs:
      • dexfenfluramine
      • fluoxetine (Prozac)
      • fluvoxamine (Luvox)
      • paroxetine (Paxil)
      • sertraline (Zoloft)
      • venlafaxine (Effexor
      • Effexor XR)
    • Tell your doctor if you are taking other antidepressants, medications for blood pressure, medications for diabetes, sleeping pills, tranquilizers, vitamins or herbs.
    • This medicine may increase the affects antihypertensive drugs, drugs with sedative effects, phenytoin (Dilantin) or fosphenytoin (Celebyx) and tramadol (Ultram).
    • Do not take MAO inhibitors type A with this medicine. If you are not sure if you are taking an MAO inhibitor, talk to your doctor or pharmacist. Certain other antidepressants, clozapine (Clozaril), haloperidol (Haldol), lithium, trazadone, and others may increase the risk of seizures. BEFORE taking any new prescription or over-the-counter medicine, talk to your health care provider.
    • Patients taking MAO inhibitors should not be take this medicine.
    • Nafazodone can decrease the effects of clonidine, methyldopa, diuretics (water pills), warfarin and drugs used to lower blood sugar (hypoglycemics). This medicine can increase the toxic effects of; terfenadine, astemizole, fluoxetine (Prozac), triazolam, alprazolam (Xanax) and phenytoin (Dilantin). Do not take this medicine within 14 days of stopping MAO inhibitors. If you are not sure what an MAO inhibitor is, talk to your doctor or pharmacist. If you are currently taking any of these medicines, talk to your doctor or pharmacist to see if Nefazodone is right for you.
    • Possible drug interactions may occur with phenobarbital causing a decrease in the effect of the medications. Severe blood pressure problems and seizure can occur with taken with MAO inhibitors.
    • Talk with your physician or pharmacist if you are taking other medications.

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If you are pregnant or thinking of becoming pregnant, before taking this medicine talk to your doctor about the benefits versus the risks to your pregnancy.
In testing with animals, studies show delayed bone development. Use this medicine only if it clearly necessary. It is advised not to take this medicine while nursing. If you have any concerns, talk to your doctor or pharmacist.

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More Information

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other benefits. However, studies have shown that a small number of people (especially children/teenages) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with a doctor about the risks and benefits of antidepressant medication, even if the treatment is not for a mental condition. Tell your doctor immediatley if you notice worsening depression, unusual behavior changes, (including possible suicidal thoughts/attempts), or other mental/mood changes. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Copyright 2006 PharmClips, Inc. All rights reserved.
This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.

Last reviewed:

  On 8 Aug 2006

  By John M. Grohol, Psy.D.






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avatar of person


Registered: May 2015
Location: LA
Posts: 79
Wed May 20, 2015 Recommended? Yes | Total Spent: None indicated| Rating: 0 

PROS: it works
CONS: none

I usually buy prescribed drugs through americantrustpills (seriously, this place sucks) without danger. Unfortunately I use to take tons of it so low price is very important for me.

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Legendary Wise Elder

Registered: October 2004
Location: Kentucky, USA
Posts: 22325
Thu September 14, 2006 Recommended? Yes | Total Spent: None indicated| Rating: 3 

CONS: couldn't sleep, worse anxiety, nausea & weight loss, dizziness & migraine pain

This medication continued the nausea feeling, adding to my weight loss. With the increased feelings of anxiety, came the inability to sleep for days. Migraine pain was accompanied by dizziness which is a result of a drop in blood pressure. The reactions lasted too long to be able to be tollerated so the med had to be stopped.

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Veteran Member

Registered: August 2006
Location: USA
Posts: 303
Fri September 8, 2006 Recommended? No | Total Spent: None indicated| Rating: 1 

PROS: None
CONS: Food & drug interactions.

This was absolutely horrible. I got terribly sick taking this. It just never seemed to benefit me in anyway and I had too many dietary restrictions with it. I think there are much better, and newer drugs on the market that can replace this for many. I know some still benefit from it...but not me.

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Grand Poohbah

Registered: July 2004
Posts: 1563
Thu June 15, 2006 Recommended? Yes | Total Spent: $60.00| Rating: 8 

PROS: This has been the first anti-depressant to have a significant positive effect on my atypical depression.
CONS: Side effects can be bothersome, and you have to be careful to follow the diet and medication restrictions. It only comes in 15mg tablets, and may require taking a dose as often as 3 or 4 times per day.

Nardil is a good choice for those with atypical depression or depression with anxiety when other anti-depressants have not worked. The dietary and medication restrictions are excessively difficult to follow, but it does require caution and awareness to avoid an adverse reaction.

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